Parkinson's disease with depression
Conditions
Interventions
control group:sham stimulation
Sponsors
Xinhua Hospital, Affiliated to Shanghai JiaoTong University, School of Medicine
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Age ranging from 45 and 75 years. 2) clinical diagnosis with idiopathic Parkinson's disease according to the MDS 2015 criteria. 3) H&Y stage between 1 and 3 grades. 4) having depressive symptoms according to ICD -10 criteria for depression. 5) The patient or his legal guardian has agreed to participate in the trial and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Having cognitive impairment; 2) having psychiatric symptoms; 3) having histories of chronic organic dysfunction( heart, lung ,liver and kidney); 4) having other neurologic disease; 5) HAMD score above 35 points; 6) losing the ability to walk alone due to the other diseases; 7) pregnant women, women who were in lactation period or potentially pregnant; 8) patients who were alcohol or drug addictive; 9) patients who were participating other clinical trial at the recruitment of having participated other clinical trial within 30 days before this study; 10) patients who were unable to cooperate with the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the difference value between the HAMA score at baseline and the HAMA score durint the rTMS intervention period;the difference value between the HAMD score at baseline and the HAMD score durint the rTMS intervention period;the difference value between the MARDS score at baseline and the MARDS score durint the rTMS intervention period; | — |
Secondary
| Measure | Time frame |
|---|---|
| the difference value between the PDQ-8 score at baseline and the PDQ-8 score durint the rTMS intervention period;the difference value between the CGI score at baseline and the CGI score durint the rTMS intervention period;the difference value between the PDSS-2 score at baseline and the PDSS-2 score durint the rTMS intervention period;the difference value between the ESS score at baseline and the ESS score during the rTIM intervention period;the difference value betwen the RBDQ-HK score at baseline and the RBDQ-HK score during the rTMS intervention period;the difference value between the LARS score at baseline and the LARS score during the rTIMS intervention period;the difference value between the IRLSSG score at baseline and the IRLSSG score during the rTMS intervention period; | — |
Countries
China
Contacts
Public ContactQi Chen
Xinhua Hospital, Affiliated to Shanghai Jiao Tong University, School of Medicine
Outcome results
None listed