Effects of different doses of S-ketamine on perioperative cognitive dysfunction in the elderly

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100044419

Enrollment

Unknown

Registered

2021-03-18

Start date

2021-03-18

Completion date

Unknown

Last updated

2021-09-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative cognitive dysfunction

Interventions

A:0.25mg/kg dexotropic ketamine was given half an hour before the end of surgery

B:0.5mg/kg dexotropic ketamine was given half an hour before the end of surgery

C:10ug sufentanil was given half an hour before the end of surgery

Eligibility

Sex/Gender

All

Age

60 Years to 90 Years

Inclusion criteria

Inclusion criteria: Names of aged 60 cases patients with laparoscopic hernia surgery, or female, aged 65-79, 50-80 kg weight, ASA I- III level.

Exclusion criteria

Exclusion criteria: Severe cardiovascular and hepatic/renal dysfunction, preoperative history of neuropsychiatric disease, ketamine allergy, long-term use of drugs affecting neuropsychiatric function (e.g., use of narcotic analgesics, hypnotics, anti-anxiety drugs and antidepressants), preoperative MMSE score & LT;Score 23 excludes this study.

Design outcomes

Primary

Measure	Time frame
MMSE;ß-42, TNF-a, IL-1ß, IL-6;	—

Countries

China

Contacts

Public ContactLeyan Qiao

Yantai Yuhuangding Hospital

qiaoleyan@163.com+86 18705357088

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026