Acut Myloid Leukima
Conditions
Interventions
Group A:Prophylaxis after chemotherapy
Group B:Prophylaxis before chemotherapy
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
16 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) Aged 14-60 years; 2) AML (except M3, M7 and M6); 3) Cytological CR was achieved in the induction therapy; 4) At least 2 courses of MID/HID-Ara-C containing chemotherapy are planned, and the type and dose of chemotherapy drugs must be the same for both courses; 5) No other platelet growth factors were used during the study period.
Exclusion criteria
Exclusion criteria: 1) A history of MDS or AML with chronic leukemia or MPN change; 2) PLT count before RHTPO is greater than 300G/L; 3) thromboembolic diseases history; 4) Severe infection before treatment; 5) Allergic or intolerant to rhTPO; 6) Complicated with other tumors; 7) The Investigator considers that there are any other conditions which may cause the subject to fail to complete the study or which may pose a significant risk to the subject.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The duration of the CIT III level;The duration of the CIT IV level; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of different grades of CIT;Duration from first PLT below 20G/L to recovery above 20G/L, 30G/L, and 50G/L;The time of CIT happened;Number of platelet transfusions;The total amount of RHTPO per treatment course;Safety: incidence and severity of adverse events, clinically significant abnormal laboratory test results; | — |
Countries
China
Contacts
Public ContactYadan Wang
Wuhan Union Hospital West Campus
Outcome results
None listed