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Experimental study on the inhibitory effect of hypertonic effect on human posterior cataract

Experimental study on the inhibitory effect of hypertonic effect on human posterior cataract

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100044392
Enrollment
Unknown
Registered
2021-03-17
Start date
2021-03-16
Completion date
Unknown
Last updated
2021-09-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cataract

Interventions

control group:Intraocular perfusate
experimental group 1:20% mannitol injection
experimental group 2:5%NaCL

Sponsors

Shenyang Aier Excellence Eye Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients with pure age-related cataracts who can be followed up on time have no serious systemic diseases. The axial length of the eye is between 22-25mm, the preoperative corneal astigmatism is <1.00D, the corneal endothelial cell count and morphology are normal, and the nuclear hardness is classified according to Emery, all of II to IV.

Exclusion criteria

Exclusion criteria: History of internal eye surgery, history of ocular trauma; severe dry eye, corneal disease, glaucoma, chronic recurrent uveitis; retinal optic neuropathy; obvious refractive error; corneal astigmatism>1.0D; ciliary suspensory ligament relaxation, artificial Non-centered lens, post-cataract, capsulorhexis> 6mm or <5mm, and other ocular complications; the pupils cannot be sufficiently dilated or adhered before surgery, and the pupil diameter is <5mm.

Design outcomes

Primary

MeasureTime frame
Cell morphology;Number of cells;Nucleus;Cytoplasm;

Countries

China

Contacts

Public ContactTang Kaili

Shenyang Aier Excellence Eye Hospital

tkl901211@163.com+86 18642047842

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026