Valvular heart disease
Conditions
Interventions
Group CON:Give an equal volume of 0.9% sodium chloride injection for continuous pumping
Group DEX:A load dose of dexmedetomidine 1 µg/kg was given within 10 minutes before induction, and then 0.5 µg/kg/h was continuously pumped to the end of operation.
Sponsors
First Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
All
Age
30 Years to 50 Years
Inclusion criteria
Inclusion criteria: Aged 30-50 years, BMI index 18-25 kg/m2, ASA grade III-IV, NYHA grade II-III, LVEF>40%, planned to electively undergo heart valve replacement surgery under general anesthesia and cardiopulmonary bypass. Had no previous history of cardiac surgery and heart failure, and no myocardial infarction was found in the past month.
Exclusion criteria
Exclusion criteria: Bradycardia (HR= Grade IV; emergency surgery; severe infection; multiple organ diseases, such as liver, kidney, lung, musculoskeletal disease or immune system disease; patients allergic to dexmedetomidine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Systolic blood pressure, SBP;heart rates, HR;Complete Blood Count;Tryptase, TPS;cTnI; | — |
Countries
China
Contacts
Public ContactQian Jinqiao
The First Affiliated Hospital of Kunming Medical University
Outcome results
None listed