Pain
Conditions
Interventions
The morning group:tramadol 1.5mg/kg,iv
The afternoon group:tramadol 1.5mg/kg,iv
Sponsors
Department of Anesthesiology, The Second Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 65 years old; 2. ASA I-II; 3. Willing to participate and able to understand and sign informed consent; 4. BMI 18.5~28.
Exclusion criteria
Exclusion criteria: 1. Chronic pain, long-term use of analgesics and psychotropic drugs (including opioids, NSAIDs and antidepressants); 2. A history of allergy to opioids; 3. Abnormal surgical anesthesia recovery history; 4. Use sedatives and antidepressants 24 hours before surgery; 5. Patients with a history of epilepsy or a family history of epilepsy that cannot be controlled after treatment; 6. Take monoamine oxidase inhibitors or antidepressants within 15 days; 7. Perform liver surgery; 8. Abnormal liver and kidney function before surgery; 9. Pregnant women and women in childbirth; 10. Patients at high risk of emergency, satiety and reflux aspiration; 11. For any reason, it is not suitable to cooperate with the study or the researcher considers it inappropriate to be included in this study; 12. Patients with a history of severe chronic obstructive pulmonary disease (COPD severity grade III or IV), severe or uncontrolled bronchial asthma, pulmonary infection, or bronchiectasis; 13. Patients with acute coronary syndrome, persistent ventricular tachyarrhythmia, or NYHA grade III or IV severe heart disease; 14. Obese patients; 15. Participated in other drug experiments within three months; 16. Difficult airway.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pressure pain threshold;Invasive arterial blood pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate;SPO2;PaO2;PaCO2;nausea;region of interests ventilation,ROI1,ROI2,ROI3,ROI4;respiratory rate; | — |
Countries
China
Contacts
Public ContactLing Dan
Department of Anesthesiology, The Second Affiliated Hospital of Chongqing Medical University
Outcome results
None listed