major depression
Conditions
Interventions
control group:sham stimulation
experimental group:theta burst stimulation
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Meet the conditions for refractory depression (including unipolar or bipolar depression): (1) Have used 2 or more antidepressants; (2) Take full dose and full course of medication (use at least two drugs); 2. All patients gave informed consent; 3. The anesthesia risk assessment of ECT is high-risk, ECT is intolerant, and the side effects of ECT are obvious, because other reasons are unwilling to perform ECT or those who have poor efficacy after ECT.
Exclusion criteria
Exclusion criteria: 1. Those who have a history of epilepsy or a family history of epilepsy; 2. Those who have a history of traumatic brain injury or a history of craniocerebral surgery in the past year; 3. Those who have a metal foreign body in the skull or have a pacemaker; 4. Those who cannot cooperate to complete the treatment due to physical illness; 5. Those who cannot cooperate with the investigator due to cognitive impairment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cortisol;ACTH;Blood routine;Interleukin-1;Interleukin-8;Interleukin-6;C reactive protein;TNF-a;FT3;FT4;TSH; | — |
Countries
China
Contacts
Public ContactDu Lian
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed