The effect of perioperative low-dose S(+)-ketamine on postoperative cognitive function in elderly patients: a single center randomized controlled trial

The effect of perioperative low-dose S(+)-ketamine on postoperative cognitive function and pain in elderly patients: a single center randomized controlled trial

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100044342

Enrollment

Unknown

Registered

2021-03-16

Start date

2021-04-20

Completion date

Unknown

Last updated

2021-09-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Elderly patients with elective surgery

Interventions

A group:low-dose S(+)-ketamine

Control group:0.9% Normal saline

Eligibility

Sex/Gender

All

Age

65 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Aged >=65 years; 2. ASA I-III; 3. Subjects undergoing elective general anesthesia.

Exclusion criteria

Exclusion criteria: 1. Chronic pain with long-term use of analgesics, psychiatric drugs (including opioids, NSAIDs, sedatives, antidepressants), alcohol abuse; 2. Preoperative liver and renal function (ALT, AST, BUN, Cr) were abnormally increased; 3. Abnormal surgical anesthesia recovery history; 4. Patients with unstable ischemic heart disease and severe cardiac insufficiency; 5. Participated in other drug trials within three months; 6. Inclusion in this study was considered inappropriate.

Design outcomes

Primary

Measure	Time frame
MMSE, CAM;	—

Countries

China

Contacts

Public ContactMuhuo Ji

The Second Affiliated Hospital of Nanjing Medical University

jimuhuo2009@sina.com+86 15996235006

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026