preeclmapsia
Conditions
Interventions
Normal group:Nil
preeclampsia:Nil
Sponsors
Guangzhou Women and Children's Medical Center
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria of normal group: Normal pregnant women refer to natural pregnancy, normal full-term pregnant women, refers to those who do not have any complications and give birth to live infants without abnormal phenotype. Inclusion criteria of preeclampsia group: Mild PE pregnant women group (l-pe): systolic blood pressure >= 140 mmHg and / or diastolic blood pressure >= 90 mmHg after 20 weeks of gestation, accompanied by any of the following: urinary protein >= 0.3 g/24 h. Or urinary protein / creatinine ratio >=0.3, or random urinary protein >= (+) (the examination method when the urinary protein can not be quantified); no proteinuria but with any of the following organs or systems involved: heart, lung, liver, kidney and other important organs, or abnormal changes in the blood system, digestive system, nervous system, placenta fetus involved, etc. Severe PE pregnant women group (s-pe): PE pregnant women with any of the following symptoms can be diagnosed as s-pe: (1) continuous increase of blood pressure: systolic blood pressure >= 160 mmHg and / or diastolic blood pressure >= 110 mmHg MmHg; (2) persistent headache, visual impairment or other abnormalities of the central nervous system; (3) persistent upper abdominal pain and liver subcapsular hematoma or liver rupture; (4) abnormal liver enzymes: elevated serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST); (5) impaired renal function: urinary protein > 2.0g/24 h; oliguria (24 h urine volume < 400); (6) hypoproteinemia with ascites, pleural effusion or pericardial effusion; (7) abnormal blood system: the platelet count decreased continuously and was lower than 0 The results showed that the blood lactate dehydrogenase (LDH) level 100x10^9/L; microvascular hemolysis [anemia, jaundice or increased LDH level]; (8) heart failure; (9) pulmonary edema; (10) fetal growth restriction or oligohydramnios, intrauterine fetal death, placental abruption, etc.
Exclusion criteria
Exclusion criteria: Exclusion criteria for normal group: pregnancy injury (fetal malformation, abortion, premature birth, trophoblastic disease, etc.); twin and multiple pregnancies; high risk pregnancy complications (GDM); individuals taking drugs (especially aspirin, antibiotics), alcohol intake, individuals with risk factors, such as obesity, primary cardiovascular disease, liver and kidney disease, systemic lupus erythematosus, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cell types; | — |
Countries
China
Contacts
Public ContactYanwei Hu
Guangzhou Women and Children's Medical Center
Outcome results
None listed