Diabetic peripheral neuropathy
Conditions
Interventions
Sponsors
Shenzhen People Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Aged 45 to 60 years; 2. DPN group: patients with confirmed type 2 diabetes and confirmed diabetic peripheral neuropathy; 3. DM non-DPN group: patients with confirmed type 2 diabetes without typical signs and symptoms of diabetic peripheral neuropathy or abnormal nerve conduction function; 4. Healthy controls: non-diabetic or pre-diabetic patients with normal nerve conduction function.
Exclusion criteria
Exclusion criteria: 1. Presence of acquired non-specific inflammatory demyelinating peripheral neuropathy, including but not limited to: Grimballi syndrome, chronic inflammatory demyelinating polyradiculoneuropathy, etc. 2. Presence of peripheral neuropathy due to other systemic diseases, including but not limited to: 1) renal failure; 2) liver failure or cirrhosis; 3) heavy alcohol abuse; 4) tumours; 5) abnormal nail function; 6) connective tissue disease; 7) unstable disease of various causes; 8) HIV infection; 3. conditions that are temporarily unsuitable for NCS testing, including but not limited to: 1) diabetic foot; 2) gout; 3) osteoarthritis of the foot; 4) hyperthermia/hypothermia due to fever; 5) presence of severe lower limb vasculopathy; 6) mental anxiety or related psychiatric disorders; 7) lower limb oedema; 4. Pregnancy; 5. administration of aldolase reduction inhibitors, including epalrestat; 6. Other reasons for inability to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| evaluation of peripheral neuropathy;blood glucose indices;Pyrrole adducts of 2,5-hexanedione; | — |
Countries
China
Contacts
Public ContactYan Wu
Shenzhen People Hospital
Outcome results
None listed