Analysis of nasal microflora in patients with chronic sinusitis of different ages based on metagenomics and 16S rRNA high-throughput sequencing

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100044314

Enrollment

Unknown

Registered

2021-03-16

Start date

2021-03-09

Completion date

Unknown

Last updated

2021-09-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Rhinosinusitis

Interventions

Elderly group:Get nasal secretions

Young group:Get nasal secretions

The control group:Get nasal secretions

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 to 75 years old; 2. Meet the EPOS 2020 diagnostic criteria for chronic sinusitis; 3. There is no restriction on gender, only Chinese.

Exclusion criteria

Exclusion criteria: (1) Patients who are participating in other clinical trials; (2) Patients with odontogenic rhinosinusitis, fungal ball and isolated bone complex obstruction; (3) The patient received systemic steroid or antibiotic treatment within 4 weeks before and after the operation; (4) Patients with cystic fibrosis or autoimmune or granulomatous diseases or patients receiving immune-guided monoclonal antibodies.

Design outcomes

Primary

Measure	Time frame
bacteriological changes and epithelial cell dysfunction;	—

Countries

China

Contacts

Public ContactFang Chen

Department of Otorhinolaryngology-Head and Neck Surgery, Guangzhou Red Cross Hospital, Medical College, Ji'nan University

chenfang9411@163.com+86 15626041090

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026