postpartum depression
Conditions
Interventions
experimental group:Intravenous 0.25mg/kg Esketamine hydrochloride (diluted to 20ml with normal saline) 10 minutes after delivery
control group:Intravenous injection of 20ml normal saline 10 minutes after delivery
Sponsors
The First Affiliated Hospital of Jinan University
Eligibility
Sex/Gender
Female
Age
22 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1) Aged 22 to 40 years; 2) ASA I-II grade; 3) The fetus is well developed, single fetus, term pregnancy.
Exclusion criteria
Exclusion criteria: 1) Contraindication of combined spinal and epidural anesthesia; 2) Allergic to Esketamine or local anesthetic or opioids ; 3) Patients with serious cardiovascular and cerebrovascular diseases, severe abnormal liver and kidney function and other important organ failure; 4) Patients with mental symptoms; 5) Patients with poorly controlled or untreated hypertension (resting systolic/diastolic blood pressure greater than 180/100mmHg); 6) Patients with hyperthyroidism; 7) Patients taking psychiatric drugs or opioids for a long time before surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| depressive symptom;Pain degree; | — |
Secondary
| Measure | Time frame |
|---|---|
| vital signs;Intraoperative dverse reactions;Level of Sedation;postoperative complications;The use of vasoactive drugs;Additional epidural medication;First time out of bed;Discharge time;Anesthesia Satisfaction; | — |
Countries
China
Contacts
Public ContactYalan Li
The First Affiliated Hospital of Jinan University
Outcome results
None listed