Malignat tumor
Conditions
Interventions
Different doses groups:Ratitrexed for HIPEC
Sponsors
Changzhou Second Peopel's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years; 2. Expected survival longer than 3 months; 3. Locally advanced or metastatic colorectal cancer diagnosed by histopathology and (or) cytology; 4. At least 4 weeks elapsed between the end of the last treatment; 5. ECOG score 0 -1; 6. The patient has good liver and kidney function; 7. The subjects volunteered to participate in the experiment and signed the informed consent; 8. Use reasonable methods of contraception during medication.
Exclusion criteria
Exclusion criteria: 1. Any of the following conditions occurred during the first 6 months of enrollment:myocardial infarction, angina pectoris, congestive heart failure, transient cerebral ischemia, etc.; 2. During the first 3 months of enrollment, any of the following conditions occurred: gastric or duodenal ulcer that did not respond to treatment, erosive esophagitis or gastritis, gastrointestinal perforation, inflammatory bowel disease, pulmonary embolism, or other uncontrolled thromboembolic events; 3. AIDS-related diseases; 4. The study did not agree to use reasonable methods of contraception during treatment; 5. Bone marrow insufficiency: hemoglobin < 8.0g/dL, neutrophils < 1.5x10^9/L, platelets < 90x10^9/L; 6. Laboratory tests revealed hepatic and function insufficiency; 7. Others that researchers think should be ruled out.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood drug concentration ;Adverse reaction;security;PFS;OS; | — |
Countries
China
Contacts
Public ContactXiaolin Pu
Changzhou Second People's Hospital of Jiangsu Province
Outcome results
None listed