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Analysis of the relationship between the levels of oxytocin in cerebrospinal fluid, plasma and saliva and postpartum depression in parturients undergoing cesarean section

Analysis of the relationship between the levels of oxytocin in cerebrospinal fluid, plasma and saliva and postpartum depression in parturients undergoing cesarean section

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100044181
Enrollment
Unknown
Registered
2021-03-12
Start date
2021-04-01
Completion date
Unknown
Last updated
2022-03-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postpartum depression

Interventions

Postpartum depression group (Edinburgh Postpartum Depression scale score >= 10):Nil
Normal group (Edinburgh Postpartum Depression scale score <= 9):Nil

Sponsors

Affiliated Hospital of Xuzhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 35 Years

Inclusion criteria

Inclusion criteria: 1. The puerpera volunteered and signed the informed consent form; 2. ASA II or class III; 3. Elective cesarean section under combined spinal-epidural anesthesia; 4. 20 years old <= maternal age <= 35 years old; 5. 37 <= gestational age < 42; 6. Singleton pregnancy, fetal heart rate is good.

Exclusion criteria

Exclusion criteria: 1. Oxytocin was used before operation; 2. Past history of mental illness and familial psychosis; 3. Severe or unstable heart, liver, kidney, endocrine, blood and other internal diseases; 4. History of previous use of antidepressants and hormones; 5. Can not understand and complete the contents of the scale independently; 6. Conversion to general anesthesia during operation due to unsatisfactory anesthetic effect or other reasons; 7. Serious adverse events occurred during the operation, such as massive blood loss, amniotic fluid embolism, etc.; 8. Severe postpartum complications include abnormal uterine bleeding, puerperal infection, venous thrombosis of lower extremities, etc.; 9. Newborns are transferred to NICU or receive treatment or death due to congenital diseases or other causes within 6 weeks after delivery.

Design outcomes

Primary

MeasureTime frame
Oxytocin;

Countries

China

Contacts

Public ContactWang Zhiping

Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical University

zhpsqxt@163.com+86 13338787071

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026