A study of the correlation between cognitive function changes and fMRI brain network variation in elderly patients undergoing spinal surgery

Correlation between cognitive dysfunction and fMRI brain network changes in elderly patients undergoing spinal surgery

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100044151

Enrollment

Unknown

Registered

2021-03-11

Start date

2021-03-24

Completion date

Unknown

Last updated

2021-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative cognitive dysfunction

Interventions

case series:Nil

Eligibility

Sex/Gender

All

Age

65 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Aged more than 65 years; 2.ASA I-III; 3.Patients undergo thoracolumbar surgery,time of operation more than 2h; 4.Right handedness; 5.Written informed consent is obtained from all participants.

Exclusion criteria

Exclusion criteria: 1.Patients and controls with a history of psychiatric illness or central nervous system disease; 2.History of severe cardiovascular and cerebrovascular disease; 3.Alcoholism, drug dependence or history of cognitive-improving medications; 4.Mini-Mental State Examination (MMSE) score less than 23; 5.Visual or hearing impairments; 6.Less than 6th grade education; 7.Perioperative severe hypotension or persistent hypoxemia; 8.Cancer or patients who cannot tolerate surgical treatment; 9.Contraindications for MRI.

Design outcomes

Primary

Measure	Time frame
neuropsychological test;fMRI;	—

Countries

China

Contacts

Public ContactLiwei Wang

Xuzhou Central Hospital

doctorlww@sina.com+86 18952170255

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026