Urgent and critical illness
Conditions
Interventions
case series:Nil
Sponsors
Shanghai 10th People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. ICU patients receiving sedation, analgesia and mechanical ventilation; 2. Patients treated with voriconazole; 3. Inclusion criteria: >= 18 years old; 4. Patients with target sedation levels of RASS 0 to -2; 5. The expected stay in the ICU is at least 48 hours; 6. It has the informed consent signed by the patient himself or the legal representative of the patient if the patient does not have full civil capacity, or the informed consent signed by the person authorized by the patient if the patient is unable to sign due to illness.
Exclusion criteria
Exclusion criteria: 1. Pregnant and lactating women; 2. A history of alcohol and drug dependence; 3. A history of chronic pain; 4. Neurological and psychiatric disorders; 5. A history of liver disease or substance abuse; 6. Receiving neuromuscular blockers; 7. Blood transfusion within the last 1 week; 8. Dying and planning to abandon treatment; 9. Other conditions deemed inappropriate by the investigator to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Routine blood;biochemical test;Blood drug concentration; | — |
Countries
China
Contacts
Public ContactShuqin Zhou
Shanghai 10th People's Hospital
Outcome results
None listed