Acute Ischemic Stroke/Transient Ischemic Attack
Conditions
Interventions
1:Cilostazol combined with clopidogrel or aspirin
2:Clopidogrel combined with aspirin
Sponsors
The Fifth Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) Aged 18 or above. (2) First onset. (3) Acute non-cardiac TIA with high risk of stroke recurrence (ABCD2 score >= 4) or mild ischemic stroke patients (NIHSS score <= 3) onset within 72 hours, or ischemic stroke or TIA patients with symptomatic severe intracranial artery stenosis (stenosis rate 70% ~ 90%) within one month of onset. (4) Patients and their families signed informed consent.
Exclusion criteria
Exclusion criteria: (1) Vascular malformation, tumor, abscess or other non atherosclerotic ischemic cerebrovascular disease. (2) Isolated sensory symptoms (such as numbness), isolated visual changes, or isolated dizziness or vertigo, but there was no evidence of acute infarction on baseline CT or MRI of the head. (3) Before the occurrence of acute ischemic stroke or transient ischemic attack, they scored more than 2 points on the modified Rankin scale. (4) There are clear indications for anticoagulant therapy (assuming the cardiac origin of the embolus, such as atrial fibrillation or artificial heart valve). (5) History of intracranial hemorrhage; expected demand for long-term non research antiplatelet drugs or non steroidal anti-inflammatory drugs affecting platelet function. (6) Heparin or oral anticoagulant therapy was given within 10 days before randomization. (7) Gastrointestinal bleeding or major surgery in the first 3 months. (8) Planned or possible revascularization (any angioplasty or vascular surgery) within 3 months after screening (if clinically indicated, angiography should be performed as far as possible before randomization). (9) It is necessary to stop the planned surgery or interventional treatment of the study drug. (10) Transient ischemic attack or minor stroke caused by angiography or surgery. (11) The life expectancy is less than 3 months. (12) Women of childbearing age without reliable contraceptive measures, patients without documented negative pregnancy tests, and patients receiving other research drugs or devices. (13) Contraindications of cilostazol, aspirin and clopidogrel.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recurrence rate of stroke;modified Rankin scale; | — |
Countries
China
Contacts
Public ContactLei Zhang
The Fifth Affiliated Hospital of Sun Yat-Sen University
Outcome results
None listed