fracture and trauma of the spine
Conditions
Interventions
tranexamic acid group:early administration of 20mg/kg tranexamic acid in patients with spinal fracture
placebo group:early administration of 0.9% NS in patients with spinal fracture
Sponsors
Subei People's Hospital of Jiangsu Province
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients with thoracolumbar fracture; 2. Patients with history of trauma; 3. Older than 18 years old; 4. No obvious bleeding in other organs; 5. Patients who voluntarily participate in clinical trials and sign informed consent and have good compliance.
Exclusion criteria
Exclusion criteria: 1. Patients with osteoporotic fracture; 2. Obvious bleeding in other organs; 3. Discontinuation of oral anticoagulants or aspirin less than 1 week; 4. Allergy to tranexamic acid (TXA) or bupivacaine or have contraindications; 5. Patients at high risk of thrombosis or history of thromboembolic events; 6. Serious liver and kidney dysfunction; 7. History of seizures and epilepsy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HCT, Hb;fibrinolysis index (D-Dimer, FDP);ESR, CRP, IL-6;perioperative complications: deep vein thrombosis;Transfusion; | — |
Countries
China
Contacts
Public ContactZhang Liang
Subei People's Hospital of Jiangsu Province
Outcome results
None listed