Helicobacter pylori
Conditions
Interventions
The control group:Amoxicillin + metronidazole + esomeprazole + bismuth potassium citrate
Sponsors
Army Medical Center
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Age: 18 ~ 70 years old, male or female; (2) chronic gastritis confirmed by gastroscopy, with or without healed gastric ulcer or duodenal bulb ulcer; (3) Both urea breath test and Helicobacter pylori culture were positive. (4) No previous H.pylori eradication therapy; (5) The patient or his legal representative signed the informed consent and understood and agreed to follow the study requirements.
Exclusion criteria
Exclusion criteria: (1) PPI, potassium competitive acid blockers, antibiotics, H2 receptor antagonists, bismuth agents, probiotics and other drugs were used within four weeks before treatment; (2) Pregnant or lactating women, patients who had a birth plan during the study period; (3) Simultaneous use of non-steroidal anti-inflammatory drugs, adrenocorticosteroids, anticoagulants and alcohol abuse during treatment; (4) Patients with allergies to the drugs used in this study; (5) Other serious diseases affecting the evaluation of this study, such as severe liver disease, heart disease, kidney disease, malignant tumor, mental disease, etc.; (6) Patients with previous gastric and esophageal surgery; (7) Participated in other drug studies within the previous three months; (8) It is difficult to complete follow-up or there are other factors affecting compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient compliance;Symptoms of digestive tract were assessed before and after treatment;Incidence of adverse reactions; | — |
Countries
China
Contacts
Public ContactChun-Hui Lan
Army Medical Center
Outcome results
None listed