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The effect and mechanism of tai chi exercise on circulating exosome release and cognitive neural network remodeling in elderly patients with amnestic mild cognitive impairment

The mechanism of tai chi exercise on circulating exosome release and cognitive neural circuits remodeling

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100044083
Enrollment
Unknown
Registered
2021-03-09
Start date
2021-03-06
Completion date
Unknown
Last updated
2021-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

amnestic mild cognitive impairment

Interventions

control group:Health education

Sponsors

Fujian University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 75 Years

Inclusion criteria

Inclusion criteria: Only those who meet all the following criteria can be included in the study: 1) Diagnosed as aMCI according to Peterson's aMCI diagnostic criteria; 2) Aged between 60~75 years; 3) Fuzhou MoCA < 26, if the patients years of education below 6 years, the score will add 1 point; 4) 14-items ADL < 18; 5) Global Deterioration Scale Level: 2~3; 6) Having certain reading comprehension and communication skills and being able to cooperate in completing the scale assessment; 7) Right handedness; 8) Did not engage in regular exercise in the last three months (at least 3 times a week, at least 30 minutes of regular exercise each time); 9) Subjects were informed and volunteered to sign informed consent.

Exclusion criteria

Exclusion criteria: Those who meet any of the following criteria will not be included in the study: 1) The Geriatric Depression Scale >= 9; 2) Those suffering from severe organ failure, severe heart, cerebrovascular disease, musculoskeletal system disease and other exercise contraindications are unsuitable for Tai Chi training; 3) Patients with serious complications of stroke, such as severe lung infection, shoulder-hand syndrome, and lower limb venous embolism; 4) Patients with severe heart, liver, kidney failure, malignant tumors and other major diseases; 5) Those who are participating in other research trials that affect the results of this research.

Design outcomes

Primary

MeasureTime frame
global cognitive function;

Secondary

MeasureTime frame
memory function;executive function;quality of life;changes in brain structure and functional connectivity;Brain activity;dual-task gait;electroencephalogram patterns;

Countries

China

Contacts

Public ContactChen Lidian

Fujian University of Traditional Chinese Medicine

cld@fjtcm.edu.cn+86 591-22861989

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026