thoracic cancer
Conditions
Interventions
Ultrasound-guided paravertebral nerve block -- ropivacaine alone group (PVB group):Ultrasound-guided paravertebral nerve block was performed at 2 points T3 and T5 preoperatively, with 20ml 0.5% ropiva
Ultrasound-guided erector spinal block of chest -- ropivacaine alone group (ESPB group):Ultrasound-guided erector spinal block was performed preoperatively at the T5 level, with a total of 20ml 0.5% r
Ultrasound-guided intercostal nerve block - simple ropivacaine group (INB group):The intercostal nerve block was performed preoperatively at T3, T4, T5 and T6 intercostal nerves, with a total of 20ml
Ultrasound-guided lamina block - ropivacaine alone group (RLB group):Ultrasound-guided lamina block was performed preoperatively at the T5 level with 20ml 0.5% ropivacaine
Ultrasound-guided serratus anterior block with ropivacaine alone (SAB group):Preoperative ultrasound-guided serratus anterior plane block was performed at T3 and T5 levels, with a total of 20ml 0.5% r
Ultrasound-guided paravertebral nerve block -- ropivacaine + dexmedetomidine group (PVB-DEXM group):Ultrasound-guided paravertebral nerve block was performed at 2 points T3 and T5 preoperatively, usin
Ultrasound-guided chest erector spinal block -- ropivacaine + dexmedetomidine group (ESPB-DEXM group):Preoperative ultrasound-guided erector spinal block was performed at the T5 level, using 0.5% ropi
Ultrasound-guided intercostal nerve block - ropivacaine + dexmedetomidine group (INB-DEXM group):Preoperative intercostal nerve block was performed in the four intercostal areas T3, T4, T5 and T6, usi
Sponsors
Cancer Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Aged 20-65, the American society of anesthesiologists class I ~ II, body mass index (bmi) 18 to 25 kg/m2.
Exclusion criteria
Exclusion criteria: (1) Preoperative anemia: male Hb 37.5 degrees C; (3) Patients with preoperative pulmonary ventilation dysfunction; (4) Preoperative pulmonary infection, bronchial asthma or airway hyperresponsiveness; (5) Previous chest surgery history; (6) Cardiac function II level or above; (7) Hypertensive patients with preoperative systolic blood pressure of > 140 mmHg and/or diastolic blood pressure of BBB > mmHg; (8) Preoperative congenital heart disease, valvular disease, coronary heart disease, arrhythmia; (9) Central nervous system diseases, stroke history; (10) Complicated liver insufficiency and renal insufficiency; (11) Preoperative history of radiotherapy and chemotherapy; (12) A history of chronic preoperative pain; (13) Patients who had taken analgesics within 3 months before surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Occurrence of postoperative acute pain;The occurrence of postoperative chronic pain; | — |
Secondary
| Measure | Time frame |
|---|---|
| The total dose of opioids used within 24 hours after operation;The incidence of postoperative adverse events, including pneumothorax (blood pneumothorax, fluid pneumothorax), nausea, vomiting, dizziness, skin itching, urinary retention, drowsiness, respiratory depression, etc.;SpO2, heart rate, systolic blood pressure and diastolic blood pressure were recorded at 1h, 3h, 6h, 12h, 24h, 36h and 48h after surgery;The levels of IL-1, IL-8, IFN-?, TNF-a and other inflammatory cytokines in the blood of patients were measured on the first day, the second day, and the first, third, and sixth month after surgery, respectively, before the start of anesthesia;The proportion of CD3+, CD4+, CD8+, and CD4+/CD8+ T lymphocyte subsets in the patients' blood was measured on the first day, the second day, and the first, third, and sixth months after the surgery, respectively, before the start of anesthesia.Blood IgG, IgA, IgM levels, blood lymphocyte total number.;The postoperative quality of life of the patients was observed; | — |
Countries
China
Contacts
Public ContactQiang Wang
Cancer Hospital, Chinese Academy of Medical Sciences
Outcome results
None listed