Study on Genetic and Biological Mechanism of Common Variable Immunodeficiency Disease

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100044035

Enrollment

Unknown

Registered

2021-03-08

Start date

2020-08-01

Completion date

Unknown

Last updated

2021-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Common Variable Immunodeficiency Disease

Interventions

CVID group:Nil

health control:Nil

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Age at onset > 4 years; 2. patients with recurrent infections; 3. at least 1 immunoglobulin (mainly including IgG, IgM, IGA) level < 2 standard deviations below normal; 4. B-lymphocyte count depletion with or without decreased T-cell count.

Exclusion criteria

Exclusion criteria: 1. Hypogammaglobulinemia due to other drugs and infections; 2. other defined hypoimmunoglobulinemic disorders with a genetic background or chromosomal abnormalities (primary immunodeficiency disorders such as congenital agammaglobulinemia, transient hypogammaglobulinemia of infancy, and selective IgA deficiency).

Design outcomes

Primary

Measure	Time frame
whole genome sequencing;	—

Countries

China

Contacts

Public ContactYi Liu

West China Hospital, Sichuan University

yi2006liu@163.com+86 18980602061

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 8, 2026