cerebral small vessel disease
Conditions
Interventions
case series:Nil
Sponsors
Beijing Tiantan Hospital affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) Aged 18 - 60 years. 2) Presence of white matter hyperintensity on MRI (except for PVH Fazekas score=1 only). 3) Without hypertension (hypertension was defined as systolic blood pressure (SBP) >= 140 mmHg or diastolic blood pressure (DBP) >= 90 mmHg at admission, or having a history of hypertension or receiving antihypertensive therapy). 4) Without diabetes (diabetes was defined as patients with level of fasting plasma glucose (FPG) >= 7.0 mmol/L or 2 hour postprandial blood glucose (2hPBG)>= 11.1mmol/L or random plasma glucose (RPG) >= 11.1mmol/L or glycated hemoglobin A1c (HbA1c) concentration >= 6.5% or having a history of diabetes or receiving glucose-lowering drugs or insulin). 5) With non-traditional risk factors (with more than 1 of the following characteristics: hypotension, migraine, sleep disorders, fatigue, anxiety, chronic psychological stress, social relations disorders). 6) Independent in activities of daily life (modified Rankin Scale (mRS) <= 2). 7) Provide written informed consent.
Exclusion criteria
Exclusion criteria: 1) History of stroke, including cerebral infarction, cerebral hemorrhage, subarachnoid hemorrhage. 2) Acute cerebral infarction with the lesion showing high signal on DWI phase and the diameter > 20mm; acute subarachnoid hemorrhage or previous history of cerebrovascular malformation, aneurysmal subarachnoid hemorrhage or untreated aneurysms (> 3mm in diameter). 3) Drugs that affect autonomic nervous functions, such as adrenergic receptors and cholinesterase receptors, are being taken. 4) Diagnosed center neurodegenerative diseases (e.g. AD, PD, dementia). 5) Diagnosed autonomic nervous dysfunction diseases, such as Raynaud's disease. 6) Hereditary cerebrovascular diseases that have been diagnosed or known. 7) Presence of non-vascular white matter lesions, for example, multiple sclerosis, adult white matter dysplasia, metabolic encephalopathy or anoxic brain injury. 8) Autoimmune diseases, such as lupus erythematosus, rheumatoid arthritis. 9) Severe organic disease, such as malignant tumor, with a life expectancy less than 5 years. 10) Participate in other clinical trials at the same time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Imaging features of white matter hyperintensity;Imaging progression of white matter hyperintensity within 5 years;Clinical symptoms of the subjects;Progress of clinical characteristics of subjects within 5 years;Autonomic nervous function; | — |
Countries
China
Contacts
Public ContactYilong Wang
Beijing Tiantan Hospital affiliated to Capital Medical University
Outcome results
None listed