postoperative delirium
Conditions
Interventions
Experimental Group:Preoperative intranasal dexmedetomidine
Control group:Preoperative intranasal placebo
Sponsors
The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital)
Eligibility
Sex/Gender
All
Age
60 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 60-75 years; 2. To perform Off-pump coronary artery bypass grafting surgery; 3. Moderate mitral stenosis or insufficiency; 4. Moderate aortic stenosis or insufficiency; 5. Aortic root lesions to be operated; 6. Preoperative sleep disturbance (PSQI >= 8).
Exclusion criteria
Exclusion criteria: 1. Minimum mental state examination (MMSE) score <= 20; 2. Disagreement or inability to agree to participate in the study and/or to speak; 3. Patients with hearing disorders ; 4. Sleep apnea syndrome; 5. Ejection fraction <= 50% after admission.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Preoperative congnitive function;baseline anxiety score;Length of stay in CSICU;Myocardial infarction;Mortality rate during hospitalization;Post-intervention anxiety score;mechanical ventilation duration>12h;Hospital days;Stroke;Post-intervention sleep quality score;stroke;baseline sleep quality score; | — |
Countries
China
Contacts
Public ContactFang Jun
The First Affiliated Hospital of University of science and technology of China (Anhui Provincial Hospital)
Outcome results
None listed