Digestive Tract Disease
Conditions
Interventions
Propofol Combined with Alfentanil Group:Propofol 1.5mg/kg
Remimazolam Besylate Combined with Fentanyl Group I:Remimazolam Besylate 0.05mg/kg
Remimazolam Besylate Combined with Fentanyl Group II:Remimazolam Besylate 0.1mg/kg
Remimazolam Besylate Combined with Fentanyl Group III:Remimazolam Besylate 0.15mg/kg
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria were as follows: 1) Aged 18 - 65 years; 2) Patients undergoing painless digestive endoscopy; 3) ASA grade I or II; 4) 18kg/m2 <= BMI <= 28kg/m2; Before the trial, the nature, significance, possible benefits, possible inconvenience and potential danger of the trial should be understood in detail, and the research procedure should be understood and the informed consent should be signed voluntarily.
Exclusion criteria
Exclusion criteria: 1) If the operation time is more than or equal to 30 minutes or endoscopic treatment is needed after digestive endoscopy (such as cholangiopancreatography, endoscopic mucosal resection, endoscopic submucosal dissection, endoscopic ultrasonography, etc.); 2) Patients with sleep apnea; 3) Patients with difficult airway (modified Mahalanobis grade IV); 4) Patients with a history of upper respiratory tract infection in the last two weeks; 5) Anemia or thrombocytopenia, Hb = 2.5xuln, TBIL >= 1.5xuln, albumin ULN; 8) Hypertension patients whose blood pressure was not controlled satisfactorily by antihypertensive drugs (sitting systolic blood pressure >= 180 mmHg, diastolic blood pressure >= 100 mmHg); 9) Allergic or contraindicated to benzodiazepines, opioids, propofol and its components; 10) The patients who could not obtain informed consent or the researchers thought it was not suitable to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Integrated Pulmonary Index;Incidence of Intraoperative Respiratory Depression;Improved Anesthesia Recovery Time;Improved Anesthesia Recovery Time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Onset Time;Hemodynamic variability;Repeated Administration Rate;Patient Satisfaction; | — |
Countries
China
Contacts
Public ContactYunqi Lyu
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed