atopic dermatitis
Conditions
Interventions
test group:topical application of 0.05% propionate cream
control group:topical application of placebo cream
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
2 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Patients meeting the diagnostic criteria for AD (guidelines for Hanifin-Rajka), 1) pruritus, 2) typical morphology and distribution of the eczema, and 3. Chronic or chronically relapsing course. 2. Age from 2 to 45 years, male or female, Chinese Han population. 3.0 < SCORAD < 50 points; 4. Patients are able to understand and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Combined with other skin diseases, such as psoriasis, vitiligo, lupus erythematosus. 2. Local infection at the lesion site. 3. Patients with autoimmune diseases, such as rheumatoid arthritis. 4. A history of severe systemic disease or malignant tumor. 5. A history of systemic use of anti-inflammatory drugs within 1 month; or a history of systemic use of antibiotics and antifungal drugs within 1 month; or a history of topical use of corticosteroids, calcineurin and other anti-inflammatory drugs within 2 weeks; or a history of topical antibiotics or antifungal topical medication within 2 weeks. 6. Participated in other clinical trials in the past month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eczema area and severity index, EASI; | — |
Secondary
| Measure | Time frame |
|---|---|
| TEWL;skin hydration;visual analogue scale, VAS;investigator's global assessment, IGA;regional SCORAD; | — |
Countries
China
Contacts
Public ContactWei Li
The Department of Dermatology, Huashan Hospital, Fudan University, Shanghai
Outcome results
None listed