Heliox ventilation improves hemodynamics at high positive end expiratory pressure in elderly patients with hypertension admitted to the intensive care unit: a prospective cohort study

To investigate the possible mechanism of heliox ventilation improving pulmonary circulation of senile hypertension under high positive end expiratory pressure based on MKK3/p38MAPK pathway

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100043945

Enrollment

Unknown

Registered

2021-03-06

Start date

2021-07-01

Completion date

Unknown

Last updated

2021-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

senile hypertension

Interventions

Heliox ventilation group:Heliox ventilation

Nitrogen-oxygen ventilation group:Nitrogen-oxygen ventilation

Eligibility

Sex/Gender

All

Age

65 Years to No maximum

Inclusion criteria

Inclusion criteria: Elderly hypertensive patients over 65 years of age undergoing mechanical ventilation and hemodynamic monitoring due to respiratory failure of various causes;the inhaled oxygen concentration in the ventilator parameters maintained at 40%.

Exclusion criteria

Exclusion criteria: Secondary hypertension, shock, arrhythmia, severe heart failure (NYHA cardiac function grade III-IV), pulmonary malignancy, operation without the consent of the patient and family members.

Design outcomes

Primary

Measure	Time frame
Blood pressure;Central venous pressure;Central venous oxygen saturation;Heart rate;Plasma lactic acid;Peak airway pressure;Airway platform pressure;Plasma nitric oxide;Plasma endothelin-1;	—

Secondary

Measure	Time frame
Pulse oxygen saturation;	—

Countries

China

Contacts

Public ContactLily Zhou

Fujian Medical University Union Hospital

41120096@qq.com+86 15377906840

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 5, 2026