Skip to content

Effect of esketamine and lidocaine on early recovery quality and emotional state of patients after thyroidectomy: a randomized controlled trial

Effect of esketamine and lidocaine on early recovery quality and emotional state of patients after thyroidectomy: a randomized controlled trial

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100043935
Enrollment
Unknown
Registered
2021-03-05
Start date
2021-03-15
Completion date
Unknown
Last updated
2021-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thyroid Surgery

Interventions

Esketamine group:Esketamine
Lidocaine group: Lidocaine

Sponsors

The Affiliated Huaian Hospital of Xuzhou Medical University, Huai'an Second Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: ASA I-II, patients aged 18-65 years undergoing elective Thyroid surgery (including total thyroidectomy, subtotal thyroidectomy, radical thyroidectomy), Sign informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients with diseases of the heart, brain, lung, liver, kidney and other major organs; 2. Allergic to ketamine, lidocaine and other drugs used in the experiment; 3. Recent use of ß-blockers; 4. Patients with hypertension, diabetes or hearing impairment; 5. Pregnant and lactating women, motion sickness; 6. Moderate or above anemia (hemoglobin < 90 g/L); 7. Alcoholics and drug abusers; 8. Long-term use of sedatives, analgesics, long-term alcoholics; 9. History of mental illness, language communication difficulties, unable to understand the experimental content; 10. Adverse drug reactions, such as allergic reactions, toxic reactions, etc.; 11. The surgical blood loss was more than 100 ml; 12. The scope of operation was changed, and thyroidectomy or cervical lymph node dissection was not performed. 13. The operation time was more than 90 min. 14. Difficult airway occurs during anesthesia induction, requiring to change the routine intubation method; 15. The patient refuses to continue the study during the study.

Design outcomes

Primary

MeasureTime frame
QoR-40;SAS;SDS;

Countries

China

Contacts

Public ContactChenglan Xie

The Affiliated Huaian Hospital of Xuzhou Medical University, Huai'an Second Hospital

xiechenglan@163.com+86 13776701556

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026