Gestational Diabetes Mellitus
Conditions
Interventions
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 100 pregnant women with GDM and 50 healthy pregnant women were included and divided into three groups: 50 pregnant women with GDM wearing CGMS, 50 pregnant women without GDM wearing CGMS and 50 healthy pregnant women without CGMS. Inclusion criteria for GDM pregnant women: 1. 24-28 weeks GDM pregnant women (75g OGTT iadpsg diagnosis GDM (1) FPG >= 5.1 mmol / L or (2) 1H >= 10.0 mmol / L or (3) 2H >= 8.5 mmol / L); 2. Including caesarean section and natural birth; 3. 18.5 < BMI < 24.0kg/m2; 4. Gdma1 & gdma2; Inclusion criteria for healthy pregnant women: 1.75g OGTT iadpsg diagnosis non GDM; 2. Including caesarean section and natural birth; 3.18.5 < BMI < 24.0kg/m2.
Exclusion criteria
Exclusion criteria: 1. Twin or multiple; 2. Combined with other pregnancy diseases; 3. Combined with other diseases that may affect omics, including thyroid disease, inflammatory bowel disease, irritable bowel syndrome, celiac disease, pre pregnancy diabetes, etc.; 4. Had gastrointestinal and biliary surgery, including weight loss surgery, cholecystectomy, etc.; 5. Have a history of smoking, drinking and using narcotic drugs; 6. Long term medication history, taking oral drugs that may affect metabolism, including metformin, acarbose, betaine, antihypertensive drugs, aspirin, etc.; 7. Take drugs that affect intestinal flora, such as antibiotics, etc. in the past month, and eat probiotics, probiotics and other foods within one week; Exclusion criteria for healthy pregnant women High risk factors of GDM were excluded, including pre pregnancy obesity, type 2 diabetes mellitus in first degree relatives, GDM history, macrosomia delivery history, polycystic ovary syndrome, repeated positive fasting urine glucose in early pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CGMS dynamic blood glucose data;Blood metabonomics;Blood protein chip;Intestinal bacteria in stool; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood biochemical indexes;urinalysis;Urine SO-PGE2; | — |
Countries
China
Contacts
Public ContactYu Miao
Peking Union Medical College Hospital
Outcome results
None listed