acute respiratory failure
Conditions
Interventions
treatment group:Sedation with remimazolam tosilate
control group:Sedation with midazolam
Sponsors
Renmin Hospital of Wuhan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Above the age of 18 years old, blood gas analysis suggested that Pao2 < 60 mmhg, or Pao2/Fio2 < 200 mmhg, could not continue to receive non-invasive ventilation due to mask intolerance.
Exclusion criteria
Exclusion criteria: 1. Immediate intubation is required (PH = 85 years; 3. Severe hypotension (Mean Arterial Pressure = 4); 7. Liver failure (in accordance with the 2012 edition of the Guidelines for the Diagnosis and Treatment of Liver Failure); 8. Renal failure(diagnosed according to 2012 KDIGO clinical practice guideline for the evaluation and management of Chronic Renal Disease and Acute Renal Injury); 9. Upper gastrointestinal bleeding, perforation, obstruction; 10. Severe disturbance of consciousness (GCS < 12 points); 11. Refused to accept invasive or non-invasive mechanical ventilation by family members.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| RSAS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| the time when the RSAS score reached the target sedation level during non-invasive ventilation, the incidence of excessive sedation (RSAS 4), heart rate, blood pressure, respiratory frequency and arterial blood gas at each patient observation time point; | — |
Countries
China
Contacts
Public ContactChangyong Wang
Department of Critical Care Medicine, Renmin Hospital of Wuhan University
Outcome results
None listed