Clinical study on regeneration of nerve injury caused by intramedullary spinal cord tumors.

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100043894

Enrollment

Unknown

Registered

2021-03-04

Start date

2021-03-01

Completion date

Unknown

Last updated

2021-07-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nerve injury caused by intramedullary spinal cord tumors

Interventions

experimental group:In the experimental group, biological collagen scaffolds modified with cetuximab were transplanted after tumor resection.

control group:Routine spinal intramedullary tumor resection

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18-60 years, male or female. 2. Patients with primary intramedullary tumors of the spinal cord (ependymoma and astrocytoma). 3. Patients with acute or chronic partial spinal cord injury. 4. Nerve function score McCormick score higher than III level of patients. 5. Patients and their family members agreed to participate in the study upon request or notification, and signed the informed consent.

Exclusion criteria

Exclusion criteria: 1. The presence of myelitis and other central nervous system lesions resulting in inoperation or affecting postoperative effect observer; 2. Patients with poor general conditions and unable to tolerate surgery; 3. Patients with diseases (such as peripheral neuritis caused by severe diabetes) that may affect the results of electrophysiological examination or patients (such as epilepsy) who are not suitable for electrophysiological examination; 4. Patients with difficulty in preoperative diagnosis of cervical intramedullary tumor; 5. Patients with active infectious diseases such as hepatitis A, hepatitis B, AIDS and tuberculosis; 6. There was an active infection at the surgical site; 7. Patients with cardiac pacemakers that affect imaging and TMS-MEP examination (except for MRI compatible pacing systems); 8. Participation in other clinical trials at the same time 3 months before surgery or during the trial ; 9. Other circumstances that the investigator considers inappropriate for participation in the trial; 10. Patients with intracranial lesions; 11. Patients with allergic constitution.

Design outcomes

Primary

Measure	Time frame
Spinal cord injury ASIA score;Neuroelectrophysiological test;Neuroimaging;	—

Countries

China

Contacts

Public ContactJia Wenqing

Beijing Tiantan Hospital, Capital Medical University

coffeemd@163.com+86 10-59976507

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026