Gastroscope, colonoscopy
Conditions
Interventions
Alfentanil combined with propofol group (AP group):Alfentanil 7 µg/kg was injected intravenously during the induction period, and propofol 2 mg/kg was injected intravenously later
if the patient has physical movement or obvious swallowing movements during the operation, add propofol 0.5 mg/kg
Alfentanil combined with remazolam besylate group (AR group):Alfentanil 7 µg/kg was injected intravenously during the induction period, and remazolam besylate 0.2 mg/kg was injected intravenously late
if the patient has physical movement or obvious swallowing movements during the operation, add benzenesulfonic acid Remazolam 2.5 mg
Sufentanil combined with remazolam besylate group (SR group):Sufentanil 0.1 µg/kg was injected intravenously during the induction period, and remazolam besylate 0.2 mg/kg was injected intravenously la
if the patient exhibits physical movement or obvious swallowing movements during the operation, add benzenesulfonic acid Remazolam 2.5 mg
Sponsors
Xiang'an Hospital of Xiamen University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) Patients undergoing elective painless gastric and colonoscopy; 2) Aged 18-60 years, no gender limit; 3) Body mass index (BMI): 18.5-28 kg/m2; 4) American Association of Anesthesiologists classification (ASA): I-II; 5) Operating time within 45 min; 6) Subjects voluntarily participate in the trial and sign the informed consent form for this trial.
Exclusion criteria
Exclusion criteria: 1) Those who are allergic to opioids, benzodiazepines, propofol, flumazenil or naloxone pharmaceutical excipients; 2) Use ß-blockers, anxiolytics, and antidepressants; 3) Suspected of abuse of narcotic analgesics or tranquilizers, and alcoholics; 4) ECG prompt: heart rate 100 beats/min, or severe arrhythmia; 5) Acute respiratory infections and uncured medical history within 2 weeks; 6) Those with a history of serious heart, brain, lung, liver, kidney or metabolic diseases, those with neuromuscular system diseases (such as myasthenia gravis), or mental illness; 7) Preoperative hypertension patients with systolic blood pressure > 180 mmHg and (or) diastolic blood pressure >110 mmHg, or hypotension patients < 90/60 mmHg; 8) Those who have a history of recovery from abnormal operation anesthesia; 9) It is predicted that difficult airways may occur or have occurred, such as modified Markov classification III-IV; 10) Pregnant or lactating women and patients who have a childbirth plan within 3 months (including men); 11) Other subjects considered unsuitable to participate in this study by other researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Respiratory depression; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood pressure;heart rate;SPO2;Ramsay score; | — |
Countries
China
Contacts
Public ContactHou Lichao
Outcome results
None listed