Aplastic anemia
Conditions
Interventions
PTCY group:receive modified PTCY regimen
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
Male
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) Aged 14-60 years; 2) Gender: male or female; 3) Diagnosed with severe aplastic anemia or infusion-dependent non-severe aplastic anemia; 4) Need to receive allogeneic hematopoietic stem cell transplantation without HLA-matched sibling donors or unrelated donors; 5) General condition is acceptable, ECOG score = 50%; 7) Normal liver and kidney function: serum bilirubin <=35umol/L, AST / ALT is below twice the upper limit of normal value, serum creatinine <= 130 umol/L; 8) The subject signs the informed consent.
Exclusion criteria
Exclusion criteria: 1. Uncontrolled active infection; 2. Despite proper treatment, cholesterol > 12.95 mmol/l or triglyceride > 5.65 mmol/l and the HIV antibody positive; 3. Pregnant or breastfeeding women; 4. Infected with human immunodeficiency virus (HIV); 5. Other situations that do not meet the enrolled criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of III-IV aGVHD; | — |
Secondary
| Measure | Time frame |
|---|---|
| incidence of II-IV aGVHD;rate of engraftment;engraftment time post transplantation;incidence of cGVHD;2-year OS;2-year FFS;2-year GRFS;incidence of infection;incidence of EBV activation;incidence of CMV activation;regimen-related-toxicity; | — |
Countries
China
Contacts
Public ContactYicheng Zhang
Outcome results
None listed