Alcohol use disorder
Conditions
Interventions
experimental group1:intensive iTBS:conducting the intervention daily for 10 days in total. 5 interventions per day, each intervention lasts 5-8 min and rest for 50min in between.
control group:sham stimulation: randomazed to received either the intensive sham iTBS(25), or the normal sham iTBS(25). Turning the coil so that no magnetic field effect is generated.
experimental group2:normal iTBS:conducting the intervention daily for 10 days in total. 1 intervention per day, the intervention lasts 5-8 min
Sponsors
The Second Affiliated Hospital of Xinxiang Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Subjects meeting dsm-5 diagnostic criteria for alcohol addiction; 2. Male and female subjects, aged 18-60 years old; 3. The cognitive level of the subjects who know Chinese characters can provide informed consent and use self rating scale; 4. Right handed subjects.
Exclusion criteria
Exclusion criteria: 1. Patients with severe physical diseases or cognitive impairment (such as head trauma, cerebrovascular disease, epilepsy, etc.) are difficult to complete all interventions or MRI tests; 2. Patients with (or have suffered from) other mental diseases (except nicotine use disorder); 3. Pregnant or lactating patients; 4. Patients taking medicines that affect the central system or cognitive function in the past 10 days; 5. Patients need to take antipsychotic medicines during the intervention; 6. Patients have received TMS or tDCS treatment before; 7. Patients have any contraindications to rTMS.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| craving; | — |
Secondary
| Measure | Time frame |
|---|---|
| compulsiveness;depression;anxiety;cognition;functional connectivity;P300;electroencephalogram, EEG;Mismatch Negativity, MMN;Sympathetic skin response, SSR;blood flow of the brain;relapse;Alcohol Use Disorders Identification;sleep quality; | — |
Countries
China
Contacts
Public ContactRuiling Zhang
The Second Affiliated Hospital of Xinxiang Medical University
Outcome results
None listed