Infectious mononucleosis
Conditions
Interventions
Acyclovir treatment group:Acyclovir antiviral treatment, and general symptomatic treatment
Ganciclovir treatment group:Ganciclovir antiviral treatment, and general symptomatic treatment
Blank control group:Rehydration, heart protection, liver protection and other symptomatic treatment
Sponsors
Beijing Children's Hospital Affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with onset age of 1-18 years old; 2. Patients who meet the diagnostic criteria of infectious mononucleosis in the "recommendations on the principles of diagnosis and treatment of major non neoplastic Epstein Barr virus infection related diseases in children" formulated by the infectious diseases group of Chinese Medical Association and the National Children's Epstein Barr virus infection cooperation group in 2016; 3. Patients with persistent fever (T > 37.5 degrees C) and fever <= 5 days before hospitalization.
Exclusion criteria
Exclusion criteria: 1. Patients allergic to acyclovir and ganciclovir; 2. Patients with severe primary cardiovascular diseases, kidney diseases, liver diseases, respiratory diseases, hematological diseases, malignant tumors, endocrine and metabolic diseases, primary immunodeficiency diseases, or serious diseases affecting their survival; 3. Patients with high probability of bacterial infection according to symptoms, signs or laboratory examination; 4. Patients with steroid hormone or other immunosuppressant use history within 2 weeks before enrollment; 5. Patients with history of antiviral treatment within 2 weeks before enrollment; 6. Children with different opinions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Duration of fever; | — |
Secondary
| Measure | Time frame |
|---|---|
| Liver dysfunction;Other organs dysfunction; | — |
Countries
China
Contacts
Public ContactHuili Hu
Beijing Children's Hospital Affiliated to Capital Medical University
Outcome results
None listed