Effects of different fluid resuscitation strategies on intestinal barrier function in patients with septic shock: a pilot, prospective, randomized, controlled trial

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100043734

Enrollment

Unknown

Registered

2021-02-27

Start date

2021-04-01

Completion date

Unknown

Last updated

2021-06-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Septic Shock

Interventions

Limited fluid resuscitation group:Sodium bicarbonate ringer injection 20ml / kg, before 3 hours

Standard fluid resuscitation group:Sodium bicarbonate ringer injection 30ml / kg, before 3 hours

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Subjects over 18 years old; 2. New patients in ICU; 3. Patients with septic shock: (1) Infection; (2) SOFA score change >= 2; (3) Hypotension (map 2.5mmol/l could not be corrected by rehydration. 4. Subjects who signed informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients whose condition can't be reversed or dying; 2. The subjects who have the intention to stop or cancel the artificial life support (give up treatment); 3. Patients with chronic heart failure (heart function >= 3, New York classification); 4. In patients with severe COPD, pCO2 >= 60mmhg; 5. Pregnant or lactating women; 6. Patients who have participated in other drug / device clinical trials within 3 months.

Design outcomes

Primary

Measure	Time frame
i-FABP;	—

Secondary

Measure	Time frame
28-days Deaths;	—

Countries

China

Contacts

Public ContactChen Lei

The Sixth Affiliated Hospital of Sun Yat-Sen University

chenlei6@mail.sysu.edu.cn+86 13570236595

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026