Anesthesia
Conditions
Interventions
experimental group:Remazolam besylate for injection
Sponsors
Department of Anesthesiology, Third Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-60, regardless of gender; 2. ASA was classified as I-III; 3. 18 kg/m2 <= BMI <= 30kg/m2; 4. Non cardiothoracic and non extracerebral surgery subjects who need elective surgery under general anesthesia and need tracheal intubation; 5. Able to understand and sign the informed consent (ICF) voluntarily, and willing to comply with the requirements of the trial protocol.
Exclusion criteria
Exclusion criteria: 1. Allergic or contraindicated to benzodiazepines, opioids, propofol, flumazenil, naloxone and other drugs and their components. 2. Brain injury, possible intracranial hypertension, cerebral aneurysm, history of cerebrovascular accident and central nervous system disease; 3. Patients with mental system diseases (schizophrenia, mania, bipolar disorder, insanity, etc.), long-term history of taking psychotropic drugs and cognitive impairment; 4. Taking benzodiazepines and / or opioids intermittently within one month or nearly three months; 5. There was a history of drug abuse, drug abuse and alcohol abuse in the two years before the first visit. Alcoholism was defined as drinking more than 14 times a week on a regular basis (1 time = 150 ml wine or 360 ml beer or 45 ml spirits); 6. Pregnant or lactating women; 7. Other conditions judged by the researcher not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anesthesia induction successful;Anesthesia maintained successfully; | — |
Secondary
| Measure | Time frame |
|---|---|
| BIS value; | — |
Countries
China
Contacts
Public ContactWang Saiying, Duan Kaiming
Department of Anesthesiology, Third Xiangya Hospital of Central South University
Outcome results
None listed