schizophrenia
Conditions
Interventions
Intervention group:20Hz rTMS and drug therapy
The control group:Pseudo stimulation and drug therapy
Sponsors
The Second Affiliated Hospital of Xinxiang Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. It meets the diagnostic criteria of DSM-5 schizophrenia; 2. Age: 18-55 years old; 3. Gender: male to female ratio 1:1; 4. course of disease 2 to 5 years; 5. Antipsychotic medication was stable during transcranial magnetic stimulation; 6. Obtain the written informed consent of the patient or his legal guardian. After inclusion, they were randomly divided into intervention group and pseudo-stimulation group, with 30 cases in each group. The treatment period lasted for 4 weeks. The intervention group was given 20Hz rTMS intervention and drug therapy, and the pseudo stimulation group was given pseudo stimulation and drug therapy.
Exclusion criteria
Exclusion criteria: 1. Previous history of craniocerebral trauma, epileptic seizure, and febrile convulsion; 2. Patients with cardiac pacemaker implants or cochlear implants; 3. Currently taking clozapine treatment; 4. Abnormal EEG; 5. Patients who had received ECT in the first three months; 6. With other serious physical diseases, delirium, dementia, memory disorders, or drug or alcohol dependence, or mental retardation and unable to complete the examination; 7. Patients with or have ever suffered from drug-induced malignant syndrome or severe delayed dyskinesia; 8. Pregnant or lactating women, or planning to become pregnant; 9. Contravaindications to MRI scan.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| curative effect; | — |
Countries
China
Contacts
Public ContactDing Minli
The Second Affiliated Hospital of Xinxiang Medical University
Outcome results
None listed