Study on reducing lung injury in patients with severe ARDS by analgesia and sedation guided by P0.1

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100043678

Enrollment

Unknown

Registered

2021-02-26

Start date

2021-02-22

Completion date

Unknown

Last updated

2021-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute respiratory distress syndrome

Interventions

Group1:During 48h to 96h, the goal of analgesia and sedation was to maintain the Richmond score at 0 ~ -2. 96h-144h, the goal of analgesia and sedation is to maintain P0.1 at 0.5-1.5cmH2O

Group2:During 48h to 96h, the target of analgesia and sedation was to maintain P0.1 at 0.5-1.5cmH2O. 96h to 144h, the goal of analgesia and sedation was to maintain Richmond score at 0 ~ -2.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Aged >= 18 years; Severe ARDS patients; Invasive mechanical ventilation was performed; The mechanical ventilation time is expected to be more than 6d.

Exclusion criteria

Exclusion criteria: Incomplete data; Interruption of invasive mechanical ventilation (e.g. accidental extubation, automatic discharge, etc.) during the study period.

Design outcomes

Primary

Measure	Time frame
P0.1;SP-D;KL-6;	—

Secondary

Measure	Time frame
PaO2/FiO2;	—

Countries

China

Contacts

Public ContactWei-Zhong Wang

Shaoxing People's Hospital

906134210@qq.com+86 15958586716

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026