chronic urticaria
Conditions
Interventions
control group :to give “liang-xue-xiao-feng-san”decoction
Sponsors
Guang'anmen Hospital, China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 48 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 20 to 48 years; 2. patients conforming to the diagnostic criteria of refractory chronic urticaria; 3. patients conforming to the diagnostic criteria of TCM wind-heat syndrome; 4. patients having used at least 2 times the conventional dose of antihistamines or at least 2 combined antihistamines with conventional dose for more than 2 weeks; 5. The duration of patients'hives is more than 2 hours; 6. patients able to give stool samples; 7. patients able to sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients dignosed drug-induced urticaria, induced urticaria (cold urticaria, febrile urticaria, cholinergic urticaria), urticaria vasculitis and other skin diseases with urticaria-like manifestations; 2. patients who have been treated well with antihistamines or have been treated with hormones, immunosuppressants, or biological agents, or have received relevant Chinese medicine treatment 1 week before enrollment,or Patients who have received antibiotics and non-steroidal anti-inflammatory drugs 2 weeks before enrollment; 3. patients who are pregnant, or preparing for pregnant, or breastfeeding women; 4. patients suffering serious organic diseases of important organs such as heart, brain, liver and kidney,and those with severe primary diseases of the hematopoietic system, and those with mental illness; 5. patients allergic to the components of Chinese medicine in the research prescription.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| urticaria activity score;Itch Severity Score;Hive Severity Score;time for hives subsidence; | — |
Secondary
| Measure | Time frame |
|---|---|
| Dermatology Life Quality Index;Sleep disturbance score;Activity Impact Score; | — |
Countries
China
Contacts
Public ContactZhao Juan
Guang'anmen Hospital, China Academy of Chinese Medical Sciences
Outcome results
None listed