Acute respiratory distress syndrome
Conditions
Interventions
airway pressure release ventilation:airway pressure release ventilation
Low tidal volume protective ventilation:Low tidal volume protective ventilation
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Meet the 2012 Berlin ARDS diagnostic criteria; 2. Oxygenation index <= 250mmHg under invasive mechanical ventilation; 3. Tracheal intubation and mechanical ventilation time < 48h at the time of inclusion; 4. Sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Age less than 18 years old or more than 80 years old; 2. BMI >= 35kg/m2 in patients with obesity; 3. Pregnant and breast-feeding women; 4. The expected time of invasive mechanical ventilation is less than 48h; 5. Neuromuscular diseases that are known to require prolonged mechanical ventilation treatment; 6. Severe chronic obstructive pulmonary disease; 7. Intracranial hypertension; 8. Lung bullae or pneumothorax, subcutaneous emphysema, mediastinal emphysema; 9. ECMO treatment has been performed when entering the ICU; 10. Refractory shock; 11. Severe cardiac dysfunction (New York Heart Association grade III or IV, acute coronary syndrome or persistent ventricular tachyarrhythmia), right heart enlargement, cardiogenic shock or after major cardiac surgery; 12. Not signed informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28 days without mechanical ventilation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Days of mechanical ventilation;ICU hospitalization days;Died during ICU stay;Successful extubation;the number of days in hospital;Death during hospitalization;All-cause death 28 days after randomization;Drive pressure;Lung compliance;Platform pressure;Oxygenation index;Diaphragm activity;Diaphragm thickness;Time integral of blood flow rate of left ventricular outflow tract;Tricuspid annulus systolic displacement;Tricuspid regurgitation;Cytokines;cytology; | — |
Countries
China
Contacts
Public ContactXiaojing Zou
Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed