lung cancer
Conditions
Interventions
experimental group:Xiaoyan Decoction+Durvalumab
Sponsors
The First Teaching Hospital of Tianjin University of TCM
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Aged between 18 and 75, male and female; 2.Patients with advanced NSCLC confirmed by histopathology and/or cytology; 3.Patients with wild-type lung cancer-related driving genes such as EGFR and ALK who have received at least previous radiotherapy and chemotherapy; 4.ECOG score was 0-2; 5.Patients with advanced NSCLC whose life expectancy was at least 3 months and whose TCM syndrome differentiation was qi deficiency, poison stasis type; 6.Damage recovered from other treatments; 7.The main laboratory test indexes are normal; 8.Durvalumab can be used for treatment as determined by the attending physician; 9.Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Participated in clinical trials of other drugs within 4 weeks before the study; Or have been treated with PD-1 inhibitors, CTLA-4 inhibitors, etc.; 2. Toxicity associated with previous chemotherapy and/or radiotherapy persists; 3. Have any active autoimmune diseases or a history of autoimmune diseases; 4. Use of immunosuppressive drugs within 14 days prior to initial use of study drugs, excluding nasal spray and inhaled corticosteroids or physiological doses of systemic steroids; 5. Live attenuated vaccine was administered within 4 weeks prior to initial administration or planned during the study period; 6. Received chemotherapy or radiotherapy within 4 weeks or are currently using other anti-tumor drugs; 7. Durvalumab is known to produce allergy, hypersensitivity or intolerance; 8. Multiple factors affecting oral drug absorption (such as inability to swallow, nausea and vomiting, chronic diarrhea and intestinal obstruction, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective Response Rate;Disease Control Rate; | — |
Countries
China
Contacts
Public ContactLi Xiaojiang
The First Teaching Hospital of Tianjin University of TCM
Outcome results
None listed