Perioperative management of antithrombotic medication
Conditions
Interventions
Intervention group :standard perioperative management
Controlled group :routine perioperative management
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients who have long-term use of antithrombotic drugs for cardiovascular and cerebrovascular diseases, including antiplatelet drugs and/or anticoagulant drugs (such as aspirin, clopidogrel, ticagrelor, warfarin, dabigatran, rivaroxaban, etc.). Long-term use refers to taking above drugs continuously for more than 2 weeks and is still taking them within 1 month before admission. 2.Patients who have one or more of the following situations: (1) Non-valvular atrial fibrillation with CHA2DS2-VASc score above 4; (2) Post- artificial valve replacement(including mitral valve, ball-cage valve or tilting disc aortic valve); (3) Venous thromboembolism occurred within 1 year, or venous thromboembolism with other high-risk factors which requires long-term anticoagulation treatment;(4)Coronary heart disease with coronary stent implantation, thrombolytic therapy or other coronary procedures within 2 years, or who had undergone coronary artery bypass grafting within 1 year, or who experienced myocardial infarction or acute coronary syndrome within 1 year; (5) A history of stroke/TIA within 1 year, or a history of cervical or intracranial revascularization treatment within 1 year; (6) Peripheral arterial disease. 3.Patients who will undergo abdominal surgery (including general and urologic surgery); 4.Patients who signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. Refuse to participate; 2. Emergency surgery; 3. Unable to complete the preoperative assessment and follow-up plan; 4. There are other reasons which researcher/attending doctor think that the patient is not suitable for the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of bleeding events and major adverse cardiovascular or cerebrovascular events during perioperative period; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of overall complications during perioperative period;The length of hospital stay;hospitalization expenses;All-cause mortality rate within 30 days after surgery; | — |
Countries
China
Contacts
Public ContactHong Zhang
Peking University First Hospital
Outcome results
None listed