psoriasis
Conditions
Interventions
Sponsors
General Hospital of Ningxia Medical University
Eligibility
Sex/Gender
All
Age
15 Years to 75 Years
Inclusion criteria
Inclusion criteria: Severe plaque psoriasis, aged 18-70 years, with psoriasis area and severity index (PASI) score >= 12, course of disease >= 6 months, received at least one systemic treatment.
Exclusion criteria
Exclusion criteria: Allergy to Oxymatrine; guttate psoriasis; erythrodermic psoriasis; arthritic psoriasis; pustular psoriasis; severe liver and / or kidney damage; mental illness; hematopoietic dysfunction or other severe organ dysfunction; treatment with immunosuppressant, high-dose glucocorticoid or retinoid drugs in the past 8 weeks; 1 Medication outside the month; pregnancy or lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Psoriasis area and severity index;Oxidation antagonism;Inflammation related factors in psoriasis);Cell proliferation related factors in psoriasis;Apoptosis related factors in psoriasis;Psoriasis pathway related factors;Metabolic changes of skin and serum;Lipid composition of skin and serum;Microorganisms in skin and intestine;Genomics;Proteomics;Lipomics;Metabonomics;Pathological changes of skin;Immunohistochemical staining of skin tissue; | — |
Secondary
| Measure | Time frame |
|---|---|
| Body Surface Area (BSA);dermatology life quality index (DLQI);Physician Global Assessment (PGA); | — |
Countries
China
Contacts
Public ContactShi Huijuan
General Hospital of Ningxia Medical University
Outcome results
None listed