Sarcopenia
Conditions
Interventions
Omega-6 intervention group:Supplement 33g omega-6 daily
Omega-9 intervention group:Supplement 33g omega-9 daily
Omega-6 +omega-3 intervention group:Supplement 3g omega-3 capsules and 30g omega-6 daily
Omega-9 +omega-3 intervention group:Supplement 3g omega-3 capsules and 30g omega-9 daily
omega-3 intervention group:Supplement 3g omega-3 capsules and 30g omega-3 daily
Sponsors
Shanghai Tenth People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age 65-85 years old; 2. Patients diagnosed with sarcopenia according to the latest Asian diagnostic criteria for sarcopenia; 3. Patients with no obvious abnormalities in blood lipids (TG: 1.70~2.25mmol/L); 4. Patients who are expected to not leave their place of residence within six months and have good compliance; 5. Patients who are willing to participate in this trial and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients suffering from cardiovascular diseases, liver diseases, lung diseases, kidney diseases, severe hyperlipidemia, infectious diseases, etc.; 2. Patients who are allergic to deep-sea fish, olives, soybeans and their products; 3. Patients who have a history of using antibiotics within 2 weeks before enrollment, or who are taking drugs that affect the study (such as hormone drugs, steroid drugs, and weight loss drugs, etc.); 4. Patients with severe cognitive impairment or the history of psychotropic drug abuse; 5. Patients who are participating in other nutrition or gut microbiome intervention projects; 6. Patients who do not agree to participate in the study, cannot complete the trial, or expect to be unable to obtain follow-up data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Physical function;The bundance and diversity of fecal gut microbiome; | — |
Secondary
| Measure | Time frame |
|---|---|
| erumOmega-3 Concentration;Serum Omega-6 Concentration;Serum Omega-9 Concentration;Grip strength (Muscle strength,Biceps strength, knee extensor strength, hip flexor strength );Walking speed;fecal lipid metabolisim;blood lipids;IL-6;TNF-a;Serum albumin; | — |
Countries
China
Contacts
Public ContactYu Zhen
Shanghai Tenth People's Hospital
Outcome results
None listed