extralnodal nature killer/T-cell lymphoma, nasal type
Conditions
Interventions
Group A:50Gy radiotherapy
Group B:45Gy radiotherapy
Sponsors
Sichuan Cancer Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 75 years old; 2. Patients with extranodal nasal type NK/T cell lymphoma confirmed by histopathology (recommendation for consultation with the center for difficult pathology); 3. Ann Arbor stage I and II nasal patients; 4. After first-line chemotherapy before enrollment, the efficacy evaluation of imaging evaluation reached CR; 5. Have regular organ functions: blood routine, normal liver and kidney function (WBC >= 3.5 x 10^9/L, ANC >= 1.5 x 10^9/L, HGB > 100 g/L, PLT > 90 x 10^ 12/L, ALT, AST < 2.5ULN) 6. No other anti-tumor treatments (including anti-tumor Chinese medicines, proprietary Chinese medicines and steroid drugs); 7. Able to understand and voluntarily participate in this trial, and be able to sign informed consent; 8. Female patients of childbearing age have a negative urine pregnancy test before treatment, and all enrolled patients must agree to avoid pregnancy or cause pregnancy during the study period and within 6 months after stopping treatment 9. ECOG behavior performance status <= 2; 10. Life expectancy is greater than or equal to 3 months.
Exclusion criteria
Exclusion criteria: 1. Other types of lymphoma; 2. Ann Arbor stage III-IV; 3. Combined with any other malignant tumor history; 4. There are active infections that require treatment with systemic antibiotics or antiviral drugs and cannot receive the treatment specified in this research protocol; 5. Decompensated heart failure, dilated cardiomyopathy, coronary heart disease showing ST-segment depression on the electrocardiogram and myocardial infarction that occurred within the last 6 months; 6. Patients with severe infections or organic diseases; 7. Renal insufficiency not related to lymphoma (serum creatinine concentration exceeds 2 times the upper limit of normal); 8. Liver insufficiency not related to lymphoma (transaminase exceeding 3 times the upper limit of normal and/or blood bilirubin greater than 2.0 mg/dl); 9. There are clinical symptoms of brain dysfunction, serious mental illness; 10. Women during lactation or pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| disease-free survival, DFS;overall survival, OS; | — |
Countries
China
Contacts
Public ContactHuangming Hong
Sichuan Cancer Hospital
Outcome results
None listed