Effect of opioid-free anesthesia on recovery after breast cancer surgery

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100043575

Enrollment

Unknown

Registered

2021-02-22

Start date

2021-03-01

Completion date

Unknown

Last updated

2021-06-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

breast cancer

Interventions

OF:opioid-free anesthesia

C:opioid-containing anesthesia

Eligibility

Sex/Gender

Female

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: (1) Patients who are scheduled to undergo unilateral breast cancer surgery under general anesthesia; (2) Aged 18-60 years old; (3) ASA I-II level.

Exclusion criteria

Exclusion criteria: (1) Patients with BMI greater than 35kg/m2; (2) Patients with abnormal liver and kidney function before surgery; (3) Those who are allergic to the drugs used in the study; (4) Patients during pregnancy or lactation; (5) Patients with a history of abnormal surgical anesthesia; (6) Patients with chronic cardiovascular disease; (7) Patients with chronic pain; (8) Patients with long-term use of opioids and psychotropic drugs; (9) Patients who still cannot understand VAS or use PCA after sufficient explanation. (10) The patient rejected the participant. (11) Severe complications during the operation, such as anaphylactic shock, malignant hyperthermia, and other life-threatening patients. (12) During the operation, the chief anesthetist did not follow the established plan.

Design outcomes

Primary

Measure	Time frame
QoR-15 score 24h after operation;	—

Secondary

Measure	Time frame
QoR-15 score 3 months after operation;Chronic pain after 3 months;Sufentanil dosage within 24h after operation;VAS scores of patients at rest at 1h after operation;PCA usage within 24 hours after operation;Ramsay sedation score within 24h after operation;Extubation time;Coughing during extubation;Perioperative blood pressure;Perioperative heart rate;Postoperative nausea and vomiting;VAS scores of patients at coughing at 1h after operation;VAS scores of patients at rest at 4h after operation;VAS scores of patients at coughing at 1h after operation;VAS scores of patients at rest at 24h after operation;VAS scores of patients at coughing at 24h after operation;Other adverse reactions;usage of antiemetic;Blood lymphocyte subsets 1h after anesthesia;Blood lymphocyte subsets 24h after anesthesia;	—

Measure

Time frame

QoR-15 score 3 months after operation;Chronic pain after 3 months;Sufentanil dosage within 24h after operation;VAS scores of patients at rest at 1h after operation;PCA usage within 24 hours after operation;Ramsay sedation score within 24h after operation;Extubation time;Coughing during extubation;Perioperative blood pressure;Perioperative heart rate;Postoperative nausea and vomiting;VAS scores of patients at coughing at 1h after operation;VAS scores of patients at rest at 4h after operation;VAS scores of patients at coughing at 1h after operation;VAS scores of patients at rest at 24h after operation;VAS scores of patients at coughing at 24h after operation;Other adverse reactions;usage of antiemetic;Blood lymphocyte subsets 1h after anesthesia;Blood lymphocyte subsets 24h after anesthesia;

—

Countries

China

Contacts

Public ContactLuo qingyan

Obstetrics and Gynecology Hospital of Fudan University

wsqlqy@126.com+86 13816066319

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026