dementia
Conditions
Interventions
Sponsors
Affiliated Hospital of Guangdong Medical University
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Aged >= 50 years; (2) Dementia was diagnosed according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Revised Fifth Edition (DSMV-R), more than 1 year after the diagnosis of dementia, and more than 3 months after anti-dementia treatment; (3) Signed and dated written informed consent.
Exclusion criteria
Exclusion criteria: (1) Suffer from short bowel syndrome and gastroesophageal reflux; (2) Recurrent aspiration; (3) Immunity decreased significantly; (4) Those who do not agree to sign the informed consent of patients; (5) Take probiotics within 1 month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in ADAS-COG over 12 months; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in MMSE over 12 months;Changes in MOCA12 months;Serum levels of LPS-binding proteins were determined by enzyme-linked immunosorbent assay (ELISA) kit;Changes of fecal flora before and after treatment;Changes of serum metabolomics before and after treatment;Adverse reaction; | — |
Countries
China
Contacts
Public ContactZhou Liu
Affiliated Hospital of Guangdong Medical University
Outcome results
None listed