Type 2 diabetes
Conditions
Interventions
type 2 diabetes and healthy control group:Nil
Sponsors
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria for healthy people: 1. Age: 18-65 years old, no gender limit; 2. Physical health: no systemic diseases such as diabetes, HIV infection or genetic diseases, as well as any type of ongoing benign and malignant diseases that may interfere with the evaluation of research objectives; 3. Oral health: no oral diseases, such as leukoplakia, oral lichen planus (OLP), etc.; 4. Sign the informed consent form. Inclusion criteria for patients with type 2 diabetes 1. Age: 40-65 years old, no gender limit; 2. It meets the diagnostic criteria for diabetes and is classified as type 2; 3. Stable blood sugar control in the past 3 months; 4. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with type 1 diabetes or special type diabetes; 2. Patients with acute complications such as ketoacidosis; 3. Systemic use of antibiotics, steroid hormones, cytokines that can stimulate the body's immune system, methotrexate and other immunosuppressants in the past six months; 4. Use probiotics in large doses in the past six months (daily intake > 108cfu); 5. Use local antibiotics (such as mouthwash) in the past 7 days; 6. Systolic blood pressure >= 160mmHg or diastolic blood pressure >= 100mmHg; 7. There are obvious untreated oral abscesses, oral precancerous lesions, oral cancer, oral fungal infection, loss of more than 8 teeth and other oral diseases in the mouth; 8. Patients with other serious medical diseases such as tumor, immune system, blood system and other diseases and severe cardiopulmonary insufficiency (New York Heart Association (NYHA) heart function grade >= grade III; lung function GOLD grade >= grade III); 9. Suffering from digestive tract diseases, which can cause accurate chronic diarrhea or severe constipation. 10. Patients with impaired liver and kidney function (ALT and AST are greater than 2 times the upper limit of normal; serum creatinine is greater than the upper limit of normal); 11. Medical history of bowel resection or other gastrointestinal surgery (except appendicitis and hernia surgery) in the past 1 year. 12. History of smoking and alcoholism (except those who have stopped smoking and drinking for >= 3 months); 13. Pregnant women and lactating patients; 14. Mental illness;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Microbial composition of the digestive tract;Objectify tongue image parameters;Fecal microorganisms; | — |
Secondary
| Measure | Time frame |
|---|---|
| TCM Syndrome Scale;BMI;WC;Hips;Biochemical Indicators; | — |
Countries
China
Contacts
Public ContactHao Lu
Shanghai University of Traditional Chinese Medicine
Outcome results
None listed