Hyperbaric oxygen therapy for cognitive dysfunction induced by nitrous oxide abuse: an intervention-controlled study

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100043533

Enrollment

Unknown

Registered

2021-02-21

Start date

2021-03-01

Completion date

Unknown

Last updated

2021-06-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cognitive function induced by nitrous oxide

Interventions

experimental group:Hyperbaric oxygen therapy

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients with a clear history of N2O exposure, meeting the diagnostic criteria for substance abuse in DSM-5, 2. Who presents acute, subacute or chronic symptoms of cognitive decline, such as memory decline, disorientation, attention deficit, slower reaction, and learning disability will be eligible for inclusion. 3. Volunteer to participate in this study and sign informed consent.

Exclusion criteria

Exclusion criteria: Patients with organic brain diseases (eg, intracerebral hemorrhage, cerebral infarction), psychoactive substance abuse (in addition to alcohol, tobacco and caffeine), contraindications to hyperbaric oxygen therapy, other causes of cognitive decline.

Design outcomes

Primary

Measure	Time frame
processing speed;attention;working memory;verbal learning;visual learning;reasoning and problem solving;social cognition;Visual Continuous Attention Test;Auditory Continuous Attention Test;The Wisconsin Card Sorting Test;Raven's Standard Progressive Matrices;Stroop Colour Word Interference test;	—

Contacts

Public ContactXu Jiajun

West China Hospital of Sichuan University

xujiajun120@126.com+86 17381883373

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026